Ontology highlight
ABSTRACT:
SUBMITTER: Rowling EJ
PROVIDER: S-EPMC7496243 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Rowling Emily J EJ Miskolczi Zsofia Z Nagaraju Raghavendar R Wilcock Daniel J DJ Wang Ping P Telfer Brian B Li Yaoyong Y Lasheras-Otero Irene I Redondo-Muñoz Marta M Sharrocks Andrew D AD Arozarena Imanol I Wellbrock Claudia C
Pigment cell & melanoma research 20200320 5
A major challenge for managing melanoma is its tumour heterogeneity based on individual co-existing melanoma cell phenotypes. These phenotypes display variable responses to standard therapies, and they drive individual steps of melanoma progression; hence, understanding their behaviour is imperative. Melanoma phenotypes are defined by distinct transcriptional states, which relate to different melanocyte lineage development phases, ranging from a mesenchymal, neural crest-like to a proliferative, ...[more]