Ontology highlight
ABSTRACT:
SUBMITTER: Grab J
PROVIDER: S-EPMC7496286 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20200508 16
Fosfosal is the O-phosphorylated derivative of salicylic acid, with documented clinical use as a prodrug for the treatment of inflammatory diseases. We recently discovered that fosfosal itself inhibits the protein-protein interaction domain, the SH2 domain, of the tumor-related transcription factor STAT5b. Here, we demonstrate that fosfosal is selective for STAT5b over its close homologue STAT5a. This selectivity is mediated by the STAT5b residue Arg566, located in the SH2 domain-adjacent linker ...[more]