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Reduced Arene Complexes of Scandium.

ABSTRACT: Alkali metal naphthalenide or anthracenide reacted with scandium(III) anilides [Sc(X){N(tBu)Xy}2 (thf)] (X=N(tBu)Xy (1); X=Cl (2); Xy=C6 H3 -3,5-Me2 ) to give scandium complexes [M(thf)n ][Sc{N(tBu)Xy}2 (RA)] (M=Li-K; n=1-6; RA=C10 H8 2- (3-Naph-K) and C14 H10 2- (3-Anth-M)) containing a reduced arene ligand. Single-crystal X-ray diffraction revealed the scandium(III) center bonded to the naphthalene dianion in a ?2 :?-coordination mode, whereas the anthracene dianion is symmetrically attached to the scandium(III) center in a ?2 -fashion. All compounds have been characterized by multinuclear, including 45 Sc?NMR spectroscopy. Quantum chemical calculations of these intensely colored arene complexes confirm scandium to be in the oxidation state +3. The intense absorptions observed in the UV/Vis spectra are due to ligand-to-metal charge transfers. Whereas nitriles underwent C-C coupling reaction with the reduced arene ligand, the reaction with one equivalent of [NEt3 H][BPh4 ] led to the mono-protonation of the reduced arene ligand.

SUBMITTER: Ghana P

PROVIDER: S-EPMC7496515 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Reduced Arene Complexes of Scandium.

Ghana Priyabrata P Hoffmann Alexander A Spaniol Thomas P TP Okuda Jun J

Chemistry (Weinheim an der Bergstrasse, Germany) 20200713 45

Alkali metal naphthalenide or anthracenide reacted with scandium(III) anilides [Sc(X){N(tBu)Xy}2 (thf)] (X=N(tBu)Xy (1); X=Cl (2); Xy=C6 H3 -3,5-Me2 ) to give scandium complexes [M(thf)n ][Sc{N(tBu)Xy}2 (RA)] (M=Li-K; n=1-6; RA=C10 H8 2- (3-Naph-K) and C14 H10 2- (3-Anth-M)) containing a reduced arene ligand. Single-crystal X-ray diffraction revealed the scandium(II ...[more]

PMID: 32160350

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Project description:Herein, we describe the synthesis, full spectroscopic characterization, DFT (density functional theory) calculations, and single-crystal X-ray diffraction analyses of a series of osmium arene σ-germyl, germanate, σ-stannyl, and stannate complexes, along with their cytotoxic (anticancer) investigations. The known dimer complexes [OsCl2(η6-C6H6)]2 (1) and [OsCl2(η6-p-cymene)]2 (2) were reacted with PPh3 to form the known mononuclear complex [OsCl2(η6-p-cymene)(PPh3)] (3) and the new complex [OsCl2(η6-C6H6)(PPh3)] (6); complex 3 was reacted with GeCl2·(dioxane) and SnCl2 to afford, by insertion into the Os-Cl bond, the neutral σ-germyl and stannyl complexes [OsCl(η6-p-cymene)(PPh3)(GeCl3)] (7) and [OsCl(η6-p-cymene)(PPh3)(SnCl3)] (11), respectively, as a mixture of enantiomers. Similarly, the reaction of complex 6 with GeCl2·(dioxane) afforded [OsCl(η6-C6H6)(PPh3)(GeCl3)] (9). Complex 2, upon reaction with 1,1-bis(diphenylphosphino)methane (dppm), formed a mixture of [OsCl2(η6-p-cymene)(κ1-dppm)] (4) and [Os(η6-p-cymene)(κ2-dppm)Cl]+Cl- (5) when prepared in acetonitrile and a mixture of 4 and the dinuclear complex [[OsCl2(η6-p-cymene)]2(μ-dppm)] (0) when prepared in dichloromethane. By utilizing either isolated 4 or a mixture of 4 and 5, the synthesis of κ2-dppm germanate and stannate salts, [OsCl(η6-p-cymene)(κ2-dppm)]+GeCl3 - (8) and [OsCl(η6-p-cymene)(κ2-dppm)]+SnCl3 - (10), were accomplished via halide-abstracting reactions with GeCl2·(dioxane) or SnCl2, respectively. All resulting complexes were characterized by means of multinuclear NMR, FT-IR, ESI-MS, and UV/Vis spectroscopy. X-ray diffraction analyses of 4, 8, 9, 10, and 11 were performed and are reported. DFT studies (B3LYP, basis set LANL2DZ for Os, and def2-TZVPP for Sn, Ge, Cl, P, C, and H) were performed on complex 9 and the benzene analogue of complex 11, 11-benzene, to evaluate the structural changes and the effects on the frontier molecular orbitals arising from the substitution of Ge for Sn. Finally, complexes 3 and 7-11 were investigated for potential anticancer activities considering cell cytotoxicity and apoptosis assays against Dalton's lymphoma (DL) and Ehrlich ascites carcinoma (EAC) malignant cancer cell lines. The complexes were also tested against healthy peripheral blood mononuclear cells (PBMCs). All cell lines were also treated with the reference drug cisplatin to draw a comparison with the results obtained from the reported complexes. The study was further corroborated with in silico molecular interaction simulations and a pharmacokinetic study.

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Reduced Arene Complexes of Scandium.

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Reduced Arene Complexes of Scandium.

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