Neurocardiac regulation: from cardiac mechanisms to novel therapeutic approaches.
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ABSTRACT:
SUBMITTER: Bardsley EN
PROVIDER: S-EPMC7496613 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Neurocardiac regulation: from cardiac mechanisms to novel therapeutic approaches.
Bardsley E N EN Paterson D J DJ
The Journal of physiology 20181112 14
Cardiac sympathetic overactivity is a well-established contributor to the progression of neurogenic hypertension and heart failure, yet the underlying pathophysiology remains unclear. Recent studies have highlighted the importance of acutely regulated cyclic nucleotides and their effectors in the control of intracellular calcium and exocytosis. Emerging evidence now suggests that a significant component of sympathetic overactivity and enhanced transmission may arise from impaired cyclic nucleoti ...[more]
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