Ontology highlight
ABSTRACT:
SUBMITTER: Boons CCLM
PROVIDER: S-EPMC7496780 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Boons Christel C L M CCLM den Hartog Yvonne M YM Janssen Jeroen J W M JJWM Zandvliet Anthe S AS Vos René M RM Swart Eleonora L EL Hendrikse N Harry NH Hugtenburg Jacqueline G JG
European journal of haematology 20200416 2
<h4>Objectives</h4>Taking advantage of its food-dependent bioavailability, the present study investigated the effect of a reduced dose taken with real-life meals on the pharmacokinetics (PK) of nilotinib in chronic myeloid leukaemia (CML) patients.<h4>Methods</h4>Nilotinib was taken fasted (300 mg BID, days 1-4) or with real-life meals (200 mg BID, days 5-11). Rich sampling (days 1, 3, 8, 11) allowed for non-compartmental PK analysis. Nilotinib exposure (AUC<sub>0-12 h</sub> -C<sub>min</sub> -C ...[more]