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Photocatalytic Fluoro Sulfoximidations of Styrenes.

ABSTRACT: Reactions of difluoroiodotoluene with NH-sulfoximines provide new hypervalent iodine(III) reagents, which photocatalytically transfer a fluoro and a sulfoximidoyl group onto styrenes with high regioselectivity. The substrate scope is broad with respect to both sulfoximines and olefins. Following an operationally simple protocol, a large library of fluorine-containing N-functionalized sulfoximines can be accessed. Results from mechanistic investigations revealed the importance of radical intermediates.

SUBMITTER: Wang C

PROVIDER: S-EPMC7496861 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Photocatalytic Fluoro Sulfoximidations of Styrenes.

Wang Chenyang C Tu Yongliang Y Ma Ding D Bolm Carsten C

Angewandte Chemie (International ed. in English) 20200608 33

Reactions of difluoroiodotoluene with NH-sulfoximines provide new hypervalent iodine(III) reagents, which photocatalytically transfer a fluoro and a sulfoximidoyl group onto styrenes with high regioselectivity. The substrate scope is broad with respect to both sulfoximines and olefins. Following an operationally simple protocol, a large library of fluorine-containing N-functionalized sulfoximines can be accessed. Results from mechanistic investigations revealed the importance of radical intermed ...[more]

PMID: 32415689

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