Oxidative stress is associated with suspected non-alcoholic fatty liver disease and all-cause mortality in the general population.

ABSTRACT:

Background & aims

Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation, inflammation and an imbalanced redox homeostasis. We hypothesized that systemic free thiol levels, as a proxy of systemic oxidative stress, are associated with NAFLD.

Methods

Protein-adjusted serum free thiol concentrations were determined in participants from the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort study (n = 5562). Suspected NAFLD was defined by the Fatty Liver Index (FLI ≥ 60) and Hepatic Steatosis Index (HSI > 36).

Results

Protein-adjusted serum free thiols were significantly reduced in subjects with FLI ≥ 60 (n = 1651). In multivariable logistic regression analyses, protein-adjusted serum free thiols were associated with NA

SUBMITTER: Damba T 

PROVIDER: S-EPMC7496868 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature