Ontology highlight
ABSTRACT:
SUBMITTER: Xu H
PROVIDER: S-EPMC7496921 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Xu Haifeng H Medina-Sánchez Mariana M Schmidt Oliver G OG
Angewandte Chemie (International ed. in English) 20200609 35
An integrated system combining a magnetically-driven micromotor and a synthetized protein-based hyaluronic acid (HA) microflake is presented for the in situ selection and transport of multiple motile sperm cells (ca. 50). The system appeals for targeted sperm delivery in the reproductive system to assist fertilization or to deliver drugs. The binding mechanism between the HA microflake and sperm relies on the interactions between HA and the corresponding sperm HA receptors. Once sperm are captur ...[more]