Magnetic Micromotors for Multiple Motile Sperm Cells Capture, Transport, and Enzymatic Release.

ABSTRACT: An integrated system combining a magnetically-driven micromotor and a synthetized protein-based hyaluronic acid (HA) microflake is presented for the in situ selection and transport of multiple motile sperm cells (ca. 50). The system appeals for targeted sperm delivery in the reproductive system to assist fertilization or to deliver drugs. The binding mechanism between the HA microflake and sperm relies on the interactions between HA and the corresponding sperm HA receptors. Once sperm are captured within the HA microflake, the assembly is trapped and transported by a magnetically-driven helical microcarrier. The trapping of the sperm-microflake occurs by a local vortex induced by the microcarrier during rotation-translation under a rotating magnetic field. After transport, the microflake i

SUBMITTER: Xu H 

PROVIDER: S-EPMC7496921 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature