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Assessment of surgical tumor-free resection margins in fresh squamous-cell carcinoma resection specimens of the tongue using a clinical MRI system.


ABSTRACT: BACKGROUND:Current intraoperative methods of visual inspection and tissue palpation by the surgeon, and frozen section analysis cannot reliably prevent inadequate surgical margins in patients treated for oral squamous-cell carcinoma (OSCC). This study assessed feasibility of MRI for the assessment of surgical resection margins in fresh OSCC specimens. METHODS:Ten consecutive tongue specimens containing OSCC were scanned using 3?T clinical whole-body MRI. Two radiologists independently annotated OSCC location and minimal tumor-free margins. Whole-mount histology was the reference standard. RESULTS:The positive predictive values (PPV) and negative predictive values (NPV) for OSCC localization were 96% and 75%, and 87% and 79% for reader 1 and 2, respectively. The PPV and NPV for identification of margins <5?mm were 38% and 91%, and 5% and 87% for reader 1 and 2, respectively. CONCLUSIONS:MRI accurately localized OSCC with high inter-reader agreement in fresh OSCC specimens, but it seemed not yet feasible to accurately assess the surgical margin status.

SUBMITTER: Heidkamp J 

PROVIDER: S-EPMC7496932 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Assessment of surgical tumor-free resection margins in fresh squamous-cell carcinoma resection specimens of the tongue using a clinical MRI system.

Heidkamp Jan J   Weijs Willem L J WLJ   van Engen-van Grunsven Adriana C H ACH   de Laak-de Vries Ilse I   Maas Marnix C MC   Rovers Maroeska M MM   Fütterer Jurgen J JJ   Steens Stefan C A SCA   Takes Robert P RP  

Head & neck 20200302 8


<h4>Background</h4>Current intraoperative methods of visual inspection and tissue palpation by the surgeon, and frozen section analysis cannot reliably prevent inadequate surgical margins in patients treated for oral squamous-cell carcinoma (OSCC). This study assessed feasibility of MRI for the assessment of surgical resection margins in fresh OSCC specimens.<h4>Methods</h4>Ten consecutive tongue specimens containing OSCC were scanned using 3 T clinical whole-body MRI. Two radiologists independe  ...[more]

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