Mendelian randomisation analysis of circulating adipokines and C-reactive protein on breast cancer risk.
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ABSTRACT:
SUBMITTER: Robinson T
PROVIDER: S-EPMC7497166 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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Mendelian randomisation analysis of circulating adipokines and C-reactive protein on breast cancer risk.
Robinson Timothy T Martin Richard M RM Yarmolinsky James J
International journal of cancer 20200313 6
Circulating adipokines and C-reactive protein (CRP) have been linked to breast cancer risk in observational epidemiological studies. The causal nature of these associations is unclear because of the susceptibility of conventional observational designs to residual confounding, reverse causation and other forms of bias. Mendelian randomisation (MR) uses genetic variants as proxies for risk factors to strengthen causal inference in observational settings. We performed a MR analysis to evaluate the ...[more]
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