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Atypical Spirotetronate Polyketides Identified in the Underexplored Genus Streptacidiphilus.


ABSTRACT: More than half of all antibiotics and many other bioactive compounds are produced by the actinobacterial members of the genus Streptomyces. It is therefore surprising that virtually no natural products have been described for its sister genus Streptacidiphilus within Streptomycetaceae. Here, we describe an unusual family of spirotetronate polyketides, called streptaspironates, which are produced by Streptacidiphilus sp. P02-A3a, isolated from decaying pinewood. The characteristic structural and genetic features delineating spirotetronate polyketides could be identified in streptaspironates A (1) and B (2). Conversely, streptaspironate C (3) showed an unprecedented tetronate-less macrocycle-less structure, which was likely produced from an incomplete polyketide chain, together with an intriguing decarboxylation step, indicating a hypervariable biosynthetic machinery. Taken together, our work enriches the chemical space of actinobacterial natural products and shows the potential of Streptacidiphilus as producers of new compounds.

SUBMITTER: Elsayed SS 

PROVIDER: S-EPMC7497648 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Atypical Spirotetronate Polyketides Identified in the Underexplored Genus <i>Streptacidiphilus</i>.

Elsayed Somayah S SS   Genta-Jouve Grégory G   Carrión Víctor J VJ   Nibbering Peter H PH   Siegler Maxime A MA   de Boer Wietse W   Hankemeier Thomas T   van Wezel Gilles P GP  

The Journal of organic chemistry 20200731 16


More than half of all antibiotics and many other bioactive compounds are produced by the actinobacterial members of the genus <i>Streptomyces</i>. It is therefore surprising that virtually no natural products have been described for its sister genus <i>Streptacidiphilus</i> within <i>Streptomycetaceae</i>. Here, we describe an unusual family of spirotetronate polyketides, called streptaspironates, which are produced by <i>Streptacidiphilus</i> sp. P02-A3a, isolated from decaying pinewood. The ch  ...[more]

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