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Yttrium-Doped Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications.

ABSTRACT: Magnetic nanoparticles of Fe3O4 doped by different amounts of Y3+ (0, 0.1, 1, and 10%) ions were designed to obtain maximum heating efficiency in magnetic hyperthermia for cancer treatment. Single-phase formation was evident by X-ray diffraction measurements. An improved magnetization value was obtained for the Fe3O4 sample with 1% Y3+ doping. The specific absorption rate (SAR) and intrinsic loss of power (ILP) values for prepared colloids were obtained in water. The best results were estimated for Fe3O4 with 0.1% Y3+ ions (SAR = 194 W/g and ILP = 1.85 nHm2/kg for a magnetic field of 16 kA/m with the frequency of 413 kHz). The excellent biocompatibility with low cell cytotoxicity of Fe3O4:Y nanoparticles was observed. Immediately after magnetic hyperthermia treatment with Fe3O4:0.1%Y, a decrease in 4T1 cells' viability was observed (77% for 35 ?g/mL and 68% for 100 ?g/mL). These results suggest that nanoparticles of Fe3O4 doped by Y3+ ions are suitable for biomedical applications, especially for hyperthermia treatment.

SUBMITTER: Kowalik P

PROVIDER: S-EPMC7497709 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Yttrium-Doped Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications.

Kowalik Przemyslaw P Mikulski Jakub J Borodziuk Anna A Duda Magdalena M Kamińska Izabela I Zajdel Karolina K Rybusinski Jaroslaw J Szczytko Jacek J Wojciechowski Tomasz T Sobczak Kamil K Minikayev Roman R Kulpa-Greszta Magdalena M Pazik Robert R Grzaczkowska Paulina P Fronc Krzysztof K Lapinski Mariusz M Frontczak-Baniewicz Małgorzata M Sikora Bozena B

The journal of physical chemistry. C, Nanomaterials and interfaces 20200302 12

Magnetic nanoparticles of Fe3O4 doped by different amounts of Y3+ (0, 0.1, 1, and 10%) ions were designed to obtain maximum heating efficiency in magnetic hyperthermia for cancer treatment. Single-phase formation was evident by X-ray diffraction measurements. An improved magnetization value was obtained for the Fe3O4 sample with 1% Y3+ doping. The specific absorption rate (SAR) and intrinsic loss of power (ILP) values for prepared ...[more]

PMID: 32952770

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Yttrium-Doped Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications.

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Yttrium-Doped Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications.

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