Dataset Information

Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram.

ABSTRACT:

Purpose

To evaluate the kinetic patterns of benign and malignant breast lesions using contrast-enhanced digital mammogram (CEDM).

Methods

Women with suspicious breast lesions on mammography or ultrasound were enrolled. Single-view mediolateral oblique (MLO) CEDM of an affected breast was acquired at 2, 3, 4, 7, and 10 min after injection of contrast agent. Three readers visually and semi-quantitatively analyzed the enhancement of suspicious lesions. The kinetic pattern of each lesion was classified as persistent, plateau, or washout over two time intervals, 2-4 min and 2-10 min, by comparing the signal intensity at the first time interval with that at the second.

Results

There were 73 malignant and 75 benign lesions in 148 patients (mean age: 52 years). Benign and malignant breast lesions showed the highest signal intensity at 3 min and 2 min, respectively. Average areas under receiver operating characteristic (ROC) curve for diagnostic accuracy based on lesion enhancement at different time points were 0.73 at 2 min, 0.72 at 3 min, 0.69 at 4 min, 0.67 at 7 min, and 0.64 at 10 min. Diagnostic performance was significantly better at 2, 3, and 4 min than at 7 and 10 min (all p < 0.05). A washout kinetic pattern was significantly associated with malignant lesions at 2-4 min and 2-10 min frames according to two of the three readers' interpretations (all p ≤ 0.001).

Conclusion

Applications of optimal time intervals and kinetic patterns show promise in differentiation of benign and malignant breast lesions on CEDM.

SUBMITTER: Huang JS

PROVIDER: S-EPMC7498093 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram.

Huang Jer-Shyung JS Pan Huay-Ben HB Yang Tsung-Lung TL Hung Bao-Hui BH Chiang Chia-Ling CL Tsai Meng-Yuan MY Chou Chen-Pin CP

PloS one 20200917 9

<h4>Purpose</h4>To evaluate the kinetic patterns of benign and malignant breast lesions using contrast-enhanced digital mammogram (CEDM).<h4>Methods</h4>Women with suspicious breast lesions on mammography or ultrasound were enrolled. Single-view mediolateral oblique (MLO) CEDM of an affected breast was acquired at 2, 3, 4, 7, and 10 min after injection of contrast agent. Three readers visually and semi-quantitatively analyzed the enhancement of suspicious lesions. The kinetic pattern of each les ...[more]

PMID: 32941537

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Dataset Information

Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram.

Purpose

Methods

Results

Conclusion

Publications

Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram.

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