Unknown

Dataset Information

0

Invasive group B Streptococcus among non-pregnant adults in Brussels-Capital Region, 2005-2019.


ABSTRACT: To assess the incidence, clinical, microbiological features and outcome of invasive Streptococcus agalactiae (GBS) infections in non-pregnant adults in three tertiary hospitals of the Brussels-Capital Region. All bacterial cultures positive for GBS, from 2005 to 2019 from 3 hospitals of the Brussels-Capital Region, were extracted, and only cases of invasive diseases were included. Medical files were retrospectively retrieved for risk factors, clinical manifestations and outcome and also antibiotic-susceptibility testing and GBS serotypes. Incidence rates were calculated based on the hospitals catchment populations. A total of 337 cases of GBS-invasive infections were included. The incidence of invasive GBS for the 3 hospitals increased from 3.7 to 8.2 cases per 100.000 inhabitants between 2009 and 2018 (p = 0.04). The most frequently identified risk factors were diabetes (36.8%), obesity (35.0%), cancer (21.7%), renal disease (20.8%), and advanced age (? 65 years; 47.2%). Isolated bacteremia (22%), osteoarticular infection (21.4%), abscesses (13.9%), and skin and soft tissue infections (18.4%) were the most frequent manifestations. Intensive care unit admission was required in 21.7% and overall mortality was 9.4%. All strains remained susceptible to penicillin over the years. Up to 20% of strains were resistant to clindamycin. Serotypes Ia, Ib, II, III, IV, and V represented 96.8% of the available serotypes (60/62). As reported in several countries, invasive GBS disease in non-pregnant adults represents an increasing burden, particularly among diabetic, obese, and elderly patients. Almost all serotypes identified are included in the upcoming hexavalent GBS conjugate vaccine.

SUBMITTER: Graux E 

PROVIDER: S-EPMC7498195 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Invasive group B Streptococcus among non-pregnant adults in Brussels-Capital Region, 2005-2019.

Graux Elena E   Hites Maya M   Martiny Delphine D   Maillart Evelyne E   Delforge Marc M   Melin Pierrette P   Dauby Nicolas N  

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20200917 3


To assess the incidence, clinical, microbiological features and outcome of invasive Streptococcus agalactiae (GBS) infections in non-pregnant adults in three tertiary hospitals of the Brussels-Capital Region. All bacterial cultures positive for GBS, from 2005 to 2019 from 3 hospitals of the Brussels-Capital Region, were extracted, and only cases of invasive diseases were included. Medical files were retrospectively retrieved for risk factors, clinical manifestations and outcome and also antibiot  ...[more]

Similar Datasets

| S-EPMC5624210 | biostudies-literature
| S-EPMC8483371 | biostudies-literature
| S-EPMC7076979 | biostudies-literature
| S-EPMC7258460 | biostudies-literature
| S-EPMC7588536 | biostudies-literature
| S-EPMC4857040 | biostudies-literature
| S-EPMC3318570 | biostudies-literature
| S-EPMC5896062 | biostudies-literature
| S-EPMC3885649 | biostudies-literature
| S-EPMC5862750 | biostudies-literature