Ontology highlight
ABSTRACT:
SUBMITTER: Chikashige Y
PROVIDER: S-EPMC7498311 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Chikashige Yuji Y Kato Hiroaki H Thornton Mackenzie M Pepper Whitney W Hilgers Madelyn M Cecil Ariana A Asano Izumi I Yamada Haana H Mori Chie C Brunkow Cheyenne C Moravek Carter C Urano Takeshi T Singh Chingakham Ranjit CR Asano Katsura K
Nucleic acids research 20200901 16
The protein kinase Gcn2 is a central transducer of nutritional stress signaling important for stress adaptation by normal cells and the survival of cancer cells. In response to nutrient deprivation, Gcn2 phosphorylates eIF2α, thereby repressing general translation while enhancing translation of specific mRNAs with upstream ORFs (uORFs) situated in their 5'-leader regions. Here we performed genome-wide measurements of mRNA translation during histidine starvation in fission yeast Schizosaccharomyc ...[more]