Ontology highlight
ABSTRACT:
SUBMITTER: Sun X
PROVIDER: S-EPMC7498319 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Sun Xiaohui X Wang Yan Y Ji Kaihua K Liu Yang Y Kong Yangyang Y Nie Shasha S Li Na N Hao Jianxiu J Xie Yi Y Xu Chang C Du Liqing L Liu Qiang Q
Nucleic acids research 20200901 16
Nuclear factor erythroid 2-related factor 2 (NRF2) is a well-characterized transcription factor that protects cells against oxidative and electrophilic stresses. Emerging evidence has suggested that NRF2 protects cells against DNA damage by mechanisms other than antioxidation, yet the mechanism remains poorly understood. Here, we demonstrate that knockout of NRF2 in cells results in hypersensitivity to ionizing radiation (IR) in the presence or absence of reactive oxygen species (ROS). Under ROS ...[more]