Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC7498358 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Zhang Jingfeng J Fan Jing-Song JS Li Shuangli S Yang Yunhuang Y Sun Peng P Zhu Qinjun Q Wang Jiannan J Jiang Bin B Yang Daiwen D Liu Maili M
Nucleic acids research 20200901 16
Human Y-box binding protein 1 (YB-1) is a multifunctional protein and overexpressed in many types of cancer. It specifically recognizes DNA/RNA through a cold shock domain (CSD) and regulates nucleic acid metabolism. The C-terminal extension of CSD and the phosphorylation of S102 are indispensable for YB-1 function. Until now, the roles of the C-terminal extension and phosphorylation in gene transcription and translation are still largely unknown. Here, we solved the structure of human YB-1 CSD ...[more]