Ontology highlight
ABSTRACT:
SUBMITTER: Gremke N
PROVIDER: S-EPMC7499183 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Gremke Niklas N Polo Pierfrancesco P Dort Aaron A Schneikert Jean J Elmshäuser Sabrina S Brehm Corinna C Klingmüller Ursula U Schmitt Anna A Reinhardt Hans Christian HC Timofeev Oleg O Wanzel Michael M Stiewe Thorsten T
Nature communications 20200917 1
Cancer cells have a characteristic metabolism, mostly caused by alterations in signal transduction networks rather than mutations in metabolic enzymes. For metabolic drugs to be cancer-selective, signaling alterations need to be identified that confer a druggable vulnerability. Here, we demonstrate that many tumor cells with an acquired cancer drug resistance exhibit increased sensitivity to mechanistically distinct inhibitors of cancer metabolism. We demonstrate that this metabolic vulnerabilit ...[more]