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Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1.

ABSTRACT: Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19's pathogenesis and progression to severity. Here we demonstrate the utility of early nasopharyngeal swab samples for detection of the early expression of immune markers and the potential value of CCL2/MCP-1 in predicting disease outcome.

SUBMITTER: Sierra B

PROVIDER: S-EPMC7499702 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1.

Sierra Beatriz B Pérez Ana B AB Aguirre Eglis E Bracho Claudia C Valdés Odalys O Jimenez Narciso N Baldoquin Waldemar W Gonzalez Guelsys G Ortega Lilia M LM Montalvo Maria C MC Resik Sonia S Alvarez Delmis D Guzmán Maria G MG

Open forum infectious diseases 20200903 10

Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19's pathogenesis and progression to severity. Here we demonstrate the utility of early nasopharyngeal swab samples for detection of the early expression of immune markers and the potential value of CCL2/MCP-1 in predicting disease outcome. ...[more]

PMID: 33123608

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