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Outcomes in infants < 29 weeks of gestation following single-dose prophylactic indomethacin.

ABSTRACT: BACKGROUND:Prophylactic indomethacin (3 doses) decreases patent ductus arteriosus (PDA) and intraventricular hemorrhage (IVH) in preterm infants. The study aim was to determine whether single-dose indomethacin (SD-INDO) decreases PDA, IVH, and improves motor function. METHODS:A retrospective cohort (2007-2014) compared infants born < 29 weeks who did (n?=?299) or did not (n?=?85) receive SD-INDO and estimated outcomes association with ordinal logistic regression, adjusting for multiple variables using propensity scores. RESULTS:Infants who received SD-INDO were more premature (p?

SUBMITTER: Gillam-Krakauer M 

PROVIDER: S-EPMC7499931 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Outcomes in infants < 29 weeks of gestation following single-dose prophylactic indomethacin.

Gillam-Krakauer Maria M   Slaughter James C JC   Cotton Robert B RB   Robinson Blaine E BE   Reese Jeff J   Maitre Nathalie L NL  

Journal of perinatology : official journal of the California Perinatal Association 20200918 1

<h4>Background</h4>Prophylactic indomethacin (3 doses) decreases patent ductus arteriosus (PDA) and intraventricular hemorrhage (IVH) in preterm infants. The study aim was to determine whether single-dose indomethacin (SD-INDO) decreases PDA, IVH, and improves motor function.<h4>Methods</h4>A retrospective cohort (2007-2014) compared infants born < 29 weeks who did (n = 299) or did not (n = 85) receive SD-INDO and estimated outcomes association with ordinal logistic regression, adjusting for mul  ...[more]

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