Ontology highlight
ABSTRACT:
SUBMITTER: Ueda MT
PROVIDER: S-EPMC7499964 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Ueda Mahoko Takahashi MT Kryukov Kirill K Mitsuhashi Satomi S Mitsuhashi Hiroaki H Imanishi Tadashi T Nakagawa So S
Mobile DNA 20200917
<h4>Background</h4>Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections of mammalian germline cells. A large proportion of ERVs lose their open reading frames (ORFs), while others retain them and become exapted by the host species. However, it remains unclear what proportion of ERVs possess ORFs (ERV-ORFs), become transcribed, and serve as candidates for co-opted genes.<h4>Results</h4>We investigated characteristics of 176,401 ERV-ORFs containing retroviral-like protein d ...[more]