Ontology highlight
ABSTRACT:
SUBMITTER: Wang D
PROVIDER: S-EPMC7500824 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Wang Dongrui D Starr Renate R Chang Wen-Chung WC Aguilar Brenda B Alizadeh Darya D Wright Sarah L SL Yang Xin X Brito Alfonso A Sarkissian Aniee A Ostberg Julie R JR Li Li L Shi Yanhong Y Gutova Margarita M Aboody Karen K Badie Behnam B Forman Stephen J SJ Barish Michael E ME Brown Christine E CE
Science translational medicine 20200301 533
Although chimeric antigen receptor (CAR) T cells have demonstrated signs of antitumor activity against glioblastoma (GBM), tumor heterogeneity remains a critical challenge. To achieve broader and more effective GBM targeting, we developed a peptide-bearing CAR exploiting the GBM-binding potential of chlorotoxin (CLTX). We find that CLTX peptide binds a great proportion of tumors and constituent tumor cells. CAR T cells using CLTX as the targeting domain (CLTX-CAR T cells) mediate potent anti-GBM ...[more]