Ontology highlight
ABSTRACT:
SUBMITTER: Chen LL
PROVIDER: S-EPMC7500937 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Chen Lei-Lei LL Smith Matthew D MD Lv Lei L Nakagawa Tadashi T Li Zhijun Z Sun Shao-Cong SC Brown Nicholas G NG Xiong Yue Y Xu Yan-Ping YP
Science advances 20200918 38
TET2 DNA dioxygenase is frequently mutated in human hematopoietic malignancies and functionally inactivated in many solid tumors through a nonmutational mechanism. We recently found that TET2 mediates the interferon-JAK-STAT pathway to stimulate chemokine expression and tumor infiltration of lymphocytes (TILs). TET2 is monoubiquitylated at K1299, which promotes its activity. Here, we report that USP15 is a TET2 deubiquitinase and inhibitor. USP15 catalyzes the removal of K1299-linked monoubiquit ...[more]