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Effects of a multispecies synbiotic on glucose metabolism, lipid marker, gut microbiome composition, gut permeability, and quality of life in diabesity: a randomized, double-blind, placebo-controlled pilot study.


ABSTRACT: PURPOSE:Diabesity, the combination of obesity and type 2 diabetes, is an ever-growing global health burden. Diabesity-associated dysbiosis of the intestinal microbiome has gained attention as a potential driver of disease and, therefore, a possible therapeutic target by means of pro- or prebiotic supplementation. This study tested the effects of a multispecies synbiotic (i.e. a combination of probiotics and prebiotics) on glucose metabolism, gut microbiota, gut permeability, neutrophil function and quality of life in treatment-experienced diabesity patients. METHODS:A randomized, double-blind, placebo-controlled pilot study with 26 diabesity patients was conducted in which patients received a daily dose of a multispecies probiotic and a prebiotic (or a placebo) for 6 months. RESULTS:There were no changes in glucose metabolism or mixed meal tolerance test responses throughout the study. The analysis of secondary outcomes revealed beneficial effects on hip circumference [-?1 (95% CI -?4; 3) vs +3 (-?1; 8) cm, synbiotics vs. placebo, respectively, p?=?0.04], serum zonulin [-?0.04 (-?0.2; 0.1) vs +0.3 (-?0.05; 0.6) ng/ml, p?=?0.004)] and the physical role item of the SF36 quality of life assessment [+?5.4 (-?1.7; 12.5) vs -?5.0 (-?10.1; 0.2) points, p?=?0.02] after 3 months of intervention, and lipoprotein (a) [-?2.1 (-?5.7; 1.6) vs +3.4 (-?0.9; 7.9) mg/dl, p?=?0.02] after 6 months. There were no significant differences in alpha or beta diversity of the microbiome between groups or time points. CONCLUSIONS:Glucose metabolism as the primary outcome was unchanged during the intervention with a multispecies synbiotic in patients with diabesity. Nevertheless, synbiotics improved some symptoms and biomarkers of type 2 diabetes and aspects of quality of life suggesting a potential role as adjuvant tool in the management of diabesity.

SUBMITTER: Horvath A 

PROVIDER: S-EPMC7501130 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Effects of a multispecies synbiotic on glucose metabolism, lipid marker, gut microbiome composition, gut permeability, and quality of life in diabesity: a randomized, double-blind, placebo-controlled pilot study.

Horvath Angela A   Leber Bettina B   Feldbacher Nicole N   Tripolt Norbert N   Rainer Florian F   Blesl Andreas A   Trieb Markus M   Marsche Gunther G   Sourij Harald H   Stadlbauer Vanessa V  

European journal of nutrition 20191115 7


<h4>Purpose</h4>Diabesity, the combination of obesity and type 2 diabetes, is an ever-growing global health burden. Diabesity-associated dysbiosis of the intestinal microbiome has gained attention as a potential driver of disease and, therefore, a possible therapeutic target by means of pro- or prebiotic supplementation. This study tested the effects of a multispecies synbiotic (i.e. a combination of probiotics and prebiotics) on glucose metabolism, gut microbiota, gut permeability, neutrophil f  ...[more]

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