Ontology highlight
ABSTRACT:
SUBMITTER: Morris AH
PROVIDER: S-EPMC7501202 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Morris Aaron H AH Orbach Sophia M SM Bushnell Grace G GG Oakes Robert S RS Jeruss Jacqueline S JS Shea Lonnie D LD
Cancer research 20200514 18
Cancer metastasis poses a challenging problem both clinically and scientifically, as the stochastic nature of metastatic lesion formation introduces complexity for both early detection and the study of metastasis in preclinical models. Engineered metastatic niches represent an emerging approach to address this stochasticity by creating bioengineered sites where cancer can preferentially metastasize. As the engineered niche captures the earliest metastatic cells at a nonvital location, both nonin ...[more]