Ontology highlight
ABSTRACT:
SUBMITTER: Lou H
PROVIDER: S-EPMC7501218 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Lou Hong H Boland Joseph F JF Torres-Gonzalez Edmundo E Albanez Anaseidy A Zhou Weiyin W Steinberg Mia K MK Diaw Lena L Mitchell Jason J Roberson David D Cullen Michael M Garland Lisa L Bass Sara S Burk Robert D RD Yeager Meredith M Wentzensen Nicolas N Schiffman Mark M Freites Enrique Alvirez EA Gharzouzi Eduardo E Mirabello Lisa L Dean Michael M
Cancer research 20200706 18
Human papillomavirus (HPV) 16 displays substantial sequence variation; four HPV16 lineages (A, B, C, and D) have been described as well as multiple sublineages. To identify molecular events associated with HPV16 carcinogenesis, we evaluated viral variation, the integration of HPV16, and somatic mutation in 96 cervical cancer samples from Guatemala. A total of 65% (62/96) of the samples had integrated HPV16 sequences and integration was associated with an earlier age of diagnosis and premenopausa ...[more]