Ontology highlight
ABSTRACT:
SUBMITTER: Wandrer F
PROVIDER: S-EPMC7502042 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Wandrer Franziska F Frangež Živa Ž Liebig Stephanie S John Katharina K Vondran Florian F Wedemeyer Heiner H Veltmann Christian C Pfeffer Tobias J TJ Shibolet Oren O Schulze-Osthoff Klaus K Simon Hans-Uwe HU Bantel Heike H
Archives of toxicology 20200710 10
Amiodarone is a widely used antiarrhythmic drug that can cause the development of steatohepatitis as well as liver fibrosis and cirrhosis. The molecular mechanisms of amiodarone-mediated liver injury remain largely unknown. We therefore analyzed amiodarone-mediated hepatocellular injury in patients with chronic heart failure, in primary hepatocytes and HepG2 cells. We found that amiodarone-treated patients with chronic heart failure revealed significantly higher serum levels of caspase-cleaved k ...[more]