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Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation.

ABSTRACT: A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy.

SUBMITTER: King C

PROVIDER: S-EPMC7502355 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation.

King Charlotte C McKenna Amanda A Farzan Niloufar N Vijverberg Susanne J SJ van der Schee Marc P MP Maitland-van der Zee Anke H AH Arianto Lambang L Bisgaard Hans H BØnnelykke Klaus K Berce Vojko V PotoČnik Uros U Repnik Katja K Carleton Bruce B Daley Denise D Chew Fook Tim FT Chiang Wen Chin WC Sio Yang Yie YY Cloutier Michelle M MM Den Dekker Herman T HT Duijts Liesbeth L de Jongste Johan C JC Dijk F Nicole FN Flores Carlos C Hernandez-Pacheco Natalia N Mukhopadhyay Somnath S Basu Kaninika K Tantisira Kelan G KG Verhamme Katia M KM Celedón Juan C JC Forno Erick E Canino Glorisa G Francis Ben B Pirmohamed Munir M Sinha Ian I Hawcutt Daniel B DB

The pharmacogenomics journal 20200117 5

A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs104271 ...[more]

PMID: 31949291

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Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation.

Publications

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation.

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