Ontology highlight
ABSTRACT:
SUBMITTER: Sawatani Y
PROVIDER: S-EPMC7503545 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Sawatani Yuta Y Komiyama Yuske Y Nakashiro Koh-Ichi KI Uchida Daisuke D Fukumoto Chonji C Shimura Michiko M Hasegawa Tomonori T Kamimura Ryouta R Hitomi-Koide Masayo M Hyodo Toshiki T Kawamata Hitoshi H
International journal of molecular sciences 20200831 17
Administration of cetuximab (C-mab) in combination with paclitaxel (PTX) has been used for patients with head and neck squamous cell carcinoma (SCC) clinically. In this study, we attempted to clarify the molecular mechanisms of the enhancing anticancer effect of C-mab combined with PTX on oral SCC cells in vitro. We used two oral SCC cells (HSC4, OSC19) and A431 cells. PTX alone inhibited cell growth in all cells in a concentration-dependent manner. C-mab alone inhibited the growth of A431 and O ...[more]