Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC7503692 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Chen Jichun J Zhang Shuling S Feng Xingmin X Wu Zhijie Z Dubois Wendy W Thovarai Vishal V Ahluwalia Sonia S Gao Shouguo S Chen Jinguo J Peat Tyler T Sen Shurjo K SK Trinchieri Giorgio G Young Neal S NS Mock Beverly A BA
International journal of molecular sciences 20200826 17
Specific-pathogen-free (SPF) mice have improved hematopoietic characteristics relative to germ-free mice, however, it is not clear whether improvements in hematopoietic traits will continue when the level of microorganism exposure is further increased. We co-housed SPF C57BL/6 mice in a conventional facility (CVT) and found a significant increase in gut microbiota diversity along with increased levels of myeloid cells and T cells, especially effector memory T cells. Through single cell RNA seque ...[more]