Ontology highlight
ABSTRACT:
SUBMITTER: Ruan Y
PROVIDER: S-EPMC7503842 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200828 17
Leukemia is an aggressive hematologic neoplastic disease. Therapy-resistant leukemic stem cells (LSCs) may contribute to the relapse of the disease. LSCs are thought to be protected in the leukemia microenvironment, mainly consisting of mesenchymal stem/stromal cells (MSC), endothelial cells, and osteoblasts. Canonical and noncanonical Wnt pathways play a critical role in the maintenance of normal hematopoietic stem cells (HSC) and LSCs. In this review, we summarize recent findings on the role o ...[more]