“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability
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ABSTRACT: A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.
SUBMITTER: Gomes A
PROVIDER: S-EPMC7504088 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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