Unknown

Dataset Information

0

“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability


ABSTRACT: A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.

SUBMITTER: Gomes A 

PROVIDER: S-EPMC7504088 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9194901 | biostudies-literature
| S-EPMC9040145 | biostudies-literature
| S-EPMC7317216 | biostudies-literature
| S-EPMC4897634 | biostudies-literature
| S-EPMC5861663 | biostudies-literature
| S-EPMC3678594 | biostudies-literature
| S-EPMC7160832 | biostudies-literature
| S-EPMC5024758 | biostudies-literature
| S-EPMC9516703 | biostudies-literature
| S-EPMC8203924 | biostudies-literature