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Napthrene Compounds from Mycelial Fermentation Products of Marasmius berteroi.


ABSTRACT: The metabolites of the genus Marasmius are diverse, showing good research prospects for finding new bioactive molecules. In order to explore the active metabolites of the fungi Marasmius berteroi, the deep chemical investigation on the bioactive compounds from its cultures was undertaken, which led to the isolation of three new naphthalene compounds dipolynaphthalenes A-B (1,2) and naphthone C (3), as well as 12 known compounds (4-15). Compounds 1, 2, and 4 are dimeric naphthalene compounds. Their structures were elucidated by MS, 1D and 2D NMR spectroscopic data, as well as ECD calculations. Compounds 2-4 and 7 exhibited acetylcholinesterase (AChE) inhibitory activities at the concentration of 50 ?g/mL with inhibition ratios of 42.74%, 44.63%, 39.50% and 51.49%, respectively. Compounds 5 and 7,8 showed weak inhibitory activities towards two tumor cell lines, with IC50 of 0.10, 0.076 and 0.058 mM (K562) and 0.13, 0.18, and 0.15 mM (SGC-7901), respectively.

SUBMITTER: Yang NN 

PROVIDER: S-EPMC7504358 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Napthrene Compounds from Mycelial Fermentation Products of <i>Marasmius berteroi</i>.

Yang Ning Ning NN   Ma Qing Yun QY   Kong Fan Dong FD   Xie Qing Yi QY   Dai Hao Fu HF   Zhou Li Man LM   Yu Zhi Fang ZF   Zhao You Xing YX  

Molecules (Basel, Switzerland) 20200826 17


The metabolites of the genus <i>Marasmius</i> are diverse, showing good research prospects for finding new bioactive molecules. In order to explore the active metabolites of the fungi <i>Marasmius berteroi</i>, the deep chemical investigation on the bioactive compounds from its cultures was undertaken, which led to the isolation of three new naphthalene compounds dipolynaphthalenes A-B (<b>1</b>,<b>2</b>) and naphthone C (<b>3</b>), as well as 12 known compounds (<b>4</b>-<b>15</b>). Compounds <  ...[more]

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