Unknown

Dataset Information

0

Melatonin deficiency decreases brown adipose tissue acute thermogenic capacity of in rats measured by 18F-FDG PET.


ABSTRACT: Objective:Melatonin has been shown to increase brown adipose tissue (BAT) mass, which can lead to important metabolic effects, such as bodyweight reduction and glycemic improvement. However, BAT mass can only be measured invasively and. The gold standard for non-invasive measurement of BAT activity is positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-d-glucose (18F-FDG PET). There is no study, to our knowledge, that has evaluated if melatonin influences BAT activity, measured by this imaging technique in animals. Methods:Three experimental groups of Wistar rats (control, pinealectomy, and pinealectomy replaced with melatonin) had an 18F-FDG PET performed at room temperature and after acute cold exposure. The ratio of increased BAT activity after cold exposure/room temperature was called "acute thermogenic capacity" (ATC) We also measured UCP-1 mRNA expression to correlate with the 18F-FDG PET results. Results:Pinealectomy led to reduced acute thermogenic capacity, compared with the other groups, as well as reduced UCP1 mRNA expression. Conclusion:Melatonin deficiency impairs BAT response when exposed to acute cold exposure. These results can lead to future studies of the influence of melatonin on BAT, in animals and humans, without needing an invasive evaluation of BAT.

SUBMITTER: Halpern B 

PROVIDER: S-EPMC7504678 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

altmetric image

Publications

Melatonin deficiency decreases brown adipose tissue acute thermogenic capacity of in rats measured by <sup>18</sup>F-FDG PET.

Halpern Bruno B   Mancini Marcio C MC   Mendes Caroline C   Machado Camila Maria Longo CML   Prando Silvana S   Sapienza Marcelo Tatit MT   Buchpiguel Carlos Alberto CA   do Amaral Fernanda Gaspar FG   Cipolla-Neto José J  

Diabetology & metabolic syndrome 20200921


<h4>Objective</h4>Melatonin has been shown to increase brown adipose tissue (BAT) mass, which can lead to important metabolic effects, such as bodyweight reduction and glycemic improvement. However, BAT mass can only be measured invasively and. The gold standard for non-invasive measurement of BAT activity is positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-d-glucose (<sup>18</sup>F-FDG PET). There is no study, to our knowledge, that has evaluated if melatonin influences BAT acti  ...[more]

Similar Datasets

| S-EPMC6710246 | biostudies-literature
| S-EPMC6681694 | biostudies-literature
| S-EPMC7714432 | biostudies-literature
| S-EPMC10261398 | biostudies-literature
| S-EPMC10755331 | biostudies-literature
| S-EPMC7376767 | biostudies-literature
| S-EPMC5987871 | biostudies-literature
| S-EPMC5378483 | biostudies-literature
| S-EPMC8844259 | biostudies-literature
| S-EPMC10585555 | biostudies-literature