Ontology highlight
ABSTRACT:
SUBMITTER: Weber P
PROVIDER: S-EPMC7504770 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Weber Patrick P Thonhofer Martin M Averill Summer S Davies Gideon J GJ Santana Andres Gonzalez AG Müller Philipp P Nasseri Seyed A SA Offen Wendy A WA Pabst Bettina M BM Paschke Eduard E Schalli Michael M Torvisco Ana A Tschernutter Marion M Tysoe Christina C Windischhofer Werner W Withers Stephen G SG Wolfsgruber Andreas A Wrodnigg Tanja M TM Stütz Arnold E AE
Molecules (Basel, Switzerland) 20200903 17
Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid β-galactosidase inhibitors were prepared and their inhibitory and pharmacological chaperoning activities determined and compared with those of lipophilic analogs of the potent β-d-galactosidase inhibitor 4-<i>epi</i>-isofagomine. Structure-activity relationships were investigated by X-ray crystallography as well as by alterations in the ...[more]