Ontology highlight
ABSTRACT:
SUBMITTER: Hipolito A
PROVIDER: S-EPMC7504796 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Hipólito Ana A Nunes Sofia C SC Vicente João B JB Serpa Jacinta J
Molecules (Basel, Switzerland) 20200901 17
Metabolic remodeling is a critical skill of malignant cells, allowing their survival and spread. The metabolic dynamics and adaptation capacity of cancer cells allow them to escape from damaging stimuli, including breakage or cross-links in DNA strands and increased reactive oxygen species (ROS) levels, promoting resistance to currently available therapies, such as alkylating or oxidative agents. Therefore, it is essential to understand how metabolic pathways and the corresponding enzymatic syst ...[more]