Ontology highlight
ABSTRACT:
SUBMITTER: Andrade F
PROVIDER: S-EPMC7504815 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Andrade Felipa F Rangel-Sandoval Cinthia C Rodríguez-Hernández Alejandrina A López-Dyck Evelyn E Elizalde Alejandro A Virgen-Ortiz Adolfo A Bonales-Alatorre Edgar E Valencia-Cruz Georgina G Sánchez-Pastor Enrique E
Molecules (Basel, Switzerland) 20200830 17
The aim of this work was to determine whether Capsaicin may exert a vascular regulation through the activation of CB<sub>1</sub> and/or CB<sub>2</sub> receptors causing vasorelaxation in the rat aorta. Our results show the location of TRPV1 mainly in the endothelial and smooth muscle cells membrane. Nevertheless, Capsaicin caused vasorelaxation of this artery through a mechanism independent of TRPV1, since the specific antagonists Capsazepine and SB-366791 did not block the effect of Capsaicin. ...[more]