A20: a master regulator of arthritis.
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ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC7504854 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
A20: a master regulator of arthritis.
Wu Yongyao Y He Xiaomin X Huang Ning N Yu Jiayun J Shao Bin B
Arthritis research & therapy 20200921 1
A20, also known as TNF-α-induced protein 3 (TNFAIP3), is an anti-inflammatory protein that plays an important part in both immune responses and cell death. Impaired A20 function is associated with several human inflammatory and autoimmune diseases. Although the role of A20 in mediating inflammation has been frequently discussed, its intrinsic link to arthritis awaits further explanation. Here, we review new findings that further demonstrate the molecular mechanisms through which A20 regulates in ...[more]
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