Comprehensive tumor profiling reveals unique molecular differences between peritoneal metastases and primary colorectal adenocarcinoma.
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ABSTRACT:
SUBMITTER: Stein MK
PROVIDER: S-EPMC7505122 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Comprehensive tumor profiling reveals unique molecular differences between peritoneal metastases and primary colorectal adenocarcinoma.
Stein Matthew K MK Williard Forrest W FW Xiu Joanne J Tsao Miriam W MW Martin Michael G MG Deschner Benjamin W BW Dickson Paxton V PV Glazer Evan S ES Yakoub Danny D Shibata David D Grothey Axel F AF Philip Philip A PA Hwang Jimmy J JJ Shields Anthony F AF Marshall John L JL Korn W Michael WM Lenz Heinz-Josef HJ Deneve Jeremiah L JL
Journal of surgical oncology 20200312 8
<h4>Background and objectives</h4>Peritoneal metastases (PM) from primary colorectal cancer (pCRC) are associated with poor outcomes; however, molecular differences are not well defined.<h4>Methods</h4>We compared unpaired tumor profiles of patients with pCRC and PM from Caris Life Sciences. Testing included next-generation sequencing of 592 genes, microsatellite instability (MSI) and tumor mutational burden (TMB). Mutations were test-defined as pathogenic (PATH).<h4>Results</h4>Six hundred seve ...[more]
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