Cacna1c Hemizygosity Results in Aberrant Fear Conditioning to Neutral Stimuli.

ABSTRACT: CACNA1C, a gene that encodes an alpha-1 subunit of L-type voltage-gated calcium channels, has been strongly associated with psychiatric disorders including schizophrenia and bipolar disorder. An important objective is to understand how variation in this gene can lead to an increased risk of psychopathology. Altered associative learning has also been implicated in the pathology of psychiatric disorders, particularly in the manifestation of psychotic symptoms. In this study, we utilize auditory-cued fear memory paradigms in order to investigate whether associative learning is altered in rats hemizygous for the Cacna1c gene. Cacna1c hemizygous (Cacna1c+/-) rats and their wild-type littermates were exposed to either delay, trace, or unpaired auditory fear conditioning. All rats received a Cont

SUBMITTER: Moon AL 

PROVIDER: S-EPMC7505182 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature