Ontology highlight
ABSTRACT:
SUBMITTER: Kizhedathu A
PROVIDER: S-EPMC7505655 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Kizhedathu Amrutha A Kunnappallil Rose Sebastian RS Bagul Archit V AV Verma Puja P Guha Arjun A
eLife 20200902
Larval tracheae of <i>Drosophila</i> harbour progenitors of the adult tracheal system (tracheoblasts). Thoracic tracheoblasts are arrested in the G2 phase of the cell cycle in an ATR (mei-41)-Checkpoint Kinase1 (grapes, Chk1) dependent manner prior to mitotic re-entry. Here we investigate developmental regulation of Chk1 activation. We report that Wnt signaling is high in tracheoblasts and this is necessary for high levels of activated (phosphorylated) Chk1. We find that canonical Wnt signaling ...[more]