Ontology highlight
ABSTRACT:
SUBMITTER: Palinkas HL
PROVIDER: S-EPMC7505663 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Pálinkás Hajnalka L HL Békési Angéla A Róna Gergely G Pongor Lőrinc L Papp Gábor G Tihanyi Gergely G Holub Eszter E Póti Ádám Á Gemma Carolina C Ali Simak S Morten Michael J MJ Rothenberg Eli E Pagano Michele M Szűts Dávid D Győrffy Balázs B Vértessy Beáta G BG
eLife 20200921
Numerous anti-cancer drugs perturb thymidylate biosynthesis and lead to genomic uracil incorporation contributing to their antiproliferative effect. Still, it is not yet characterized if uracil incorporations have any positional preference. Here, we aimed to uncover genome-wide alterations in uracil pattern upon drug treatments in human cancer cell line models derived from HCT116. We developed a straightforward U-DNA sequencing method (U-DNA-Seq) that was combined with in situ super-resolution i ...[more]