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Metagenomic sequencing of stool samples in Bangladeshi infants: virome association with poliovirus shedding after oral poliovirus vaccination.

ABSTRACT: The potential role of enteric viral infections and the developing infant virome in affecting immune responses to the oral poliovirus vaccine (OPV) is unknown. Here we performed viral metagenomic sequencing on 3 serially collected stool samples from 30 Bangladeshi infants following OPV vaccination and compared findings to stool samples from 16 age-matched infants in the United States (US). In 14 Bangladeshi infants, available post-vaccination serum samples were tested for polio-neutralizing antibodies. The abundance (p?=?0.006) and richness (p?=?0.013) of the eukaryotic virome increased with age and were higher than seen in age-matched US infants (p?

SUBMITTER: Tan SK

PROVIDER: S-EPMC7506025 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Metagenomic sequencing of stool samples in Bangladeshi infants: virome association with poliovirus shedding after oral poliovirus vaccination.

Tan Susanna K SK Granados Andrea C AC Bouquet Jerome J Hoy-Schulz Yana Emmy YE Green Lauri L Federman Scot S Stryke Doug D Haggerty Thomas D TD Ley Catherine C Yeh Ming-Te MT Jannat Kaniz K Maldonado Yvonne A YA Andino Raul R Parsonnet Julie J Chiu Charles Y CY

Scientific reports 20200921 1

The potential role of enteric viral infections and the developing infant virome in affecting immune responses to the oral poliovirus vaccine (OPV) is unknown. Here we performed viral metagenomic sequencing on 3 serially collected stool samples from 30 Bangladeshi infants following OPV vaccination and compared findings to stool samples from 16 age-matched infants in the United States (US). In 14 Bangladeshi infants, available post-vaccination serum samples were tested for polio-neutralizing antib ...[more]

PMID: 32958861

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