Ontology highlight
ABSTRACT:
SUBMITTER: Yoshimoto K
PROVIDER: S-EPMC7506096 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Yoshimoto Koki K Minier Nicolas N Yang Jiandong J Imamura Satoshi S Stocking Kaylene K Patel Janmesh J Terada Shiho S Hirai Yoshikazu Y Kamei Ken-Ichiro KI
Frontiers in bioengineering and biotechnology 20200908
Hepatic development requires multiple sequential physicochemical environmental changes in an embryo, and human pluripotent stem cells (hPSCs) allow for the elucidation of this embryonic developmental process. However, the current <i>in vitro</i> methods for hPSC-hepatic differentiation, which employ various biochemical substances, produce hPSC-derived hepatocytes with less functionality than primary hepatocytes, due to a lack of physical stimuli, such as heart beating. Here, we developed a micro ...[more]