Ontology highlight
ABSTRACT:
SUBMITTER: Akerman I
PROVIDER: S-EPMC7506530 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Nature communications 20200921 1
DNA replication initiates from multiple genomic locations called replication origins. In metazoa, DNA sequence elements involved in origin specification remain elusive. Here, we examine pluripotent, primary, differentiating, and immortalized human cells, and demonstrate that a class of origins, termed core origins, is shared by different cell types and host ~80% of all DNA replication initiation events in any cell population. We detect a shared G-rich DNA sequence signature that coincides with m ...[more]