Ontology highlight
ABSTRACT:
SUBMITTER: Akerman I
PROVIDER: S-EPMC7506530 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Akerman Ildem I Kasaai Bahar B Bazarova Alina A Sang Pau Biak PB Peiffer Isabelle I Artufel Marie M Derelle Romain R Smith Gabrielle G Rodriguez-Martinez Marta M Romano Manuela M Kinet Sandrina S Tino Peter P Theillet Charles C Taylor Naomi N Ballester Benoit B Méchali Marcel M
Nature communications 20200921 1
DNA replication initiates from multiple genomic locations called replication origins. In metazoa, DNA sequence elements involved in origin specification remain elusive. Here, we examine pluripotent, primary, differentiating, and immortalized human cells, and demonstrate that a class of origins, termed core origins, is shared by different cell types and host ~80% of all DNA replication initiation events in any cell population. We detect a shared G-rich DNA sequence signature that coincides with m ...[more]