Dataset Information

Age-related functional brain connectivity during audio-visual hand-held tool recognition.

ABSTRACT: INTRODUCTION:Previous studies have confirmed increased functional connectivity in elderly adults during processing of simple audio-visual stimuli; however, it is unclear whether elderly adults maximize their performance by strengthening their functional brain connectivity when processing dynamic audio-visual hand-held tool stimuli. The present study aimed to explore this question using global functional connectivity. METHODS:Twenty-one healthy elderly adults and 21 healthy younger adults were recruited to conduct a dynamic hand-held tool recognition task with high/low-intensity stimuli. RESULTS:Elderly adults exhibited higher areas under the curve for both the high-intensity (3.5 versus. 2.7) and low-intensity (3.0 versus. 1.2) stimuli, indicating a higher audio-visual integration ability, but a delayed and widened audio-visual integration window for elderly adults for both the high-intensity (390 - 690 ms versus. 360 - 560 ms) and low-intensity (460 - 690 ms versus. 430 - 500 ms) stimuli. Additionally, elderly adults exhibited higher theta-band (all p < .01) but lower alpha-, beta-, and gamma-band functional connectivity (all p < .05) than younger adults under both the high- and low-intensity-stimulus conditions when processing audio-visual stimuli, except for gamma-band functional connectivity under the high-intensity-stimulus condition. Furthermore, higher theta- and alpha-band functional connectivity were observed for the audio-visual stimuli than for the auditory and visual stimuli and under the high-intensity-stimulus condition than under the low-intensity-stimulus condition. CONCLUSION:The higher theta-band functional connectivity in elderly adults was mainly due to higher attention allocation. The results further suggested that in the case of sensory processing, theta, alpha, beta, and gamma activity might participate in different stages of perception.

SUBMITTER: Ren Y

PROVIDER: S-EPMC7507049 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Age-related functional brain connectivity during audio-visual hand-held tool recognition.

Ren Yanna Y Guo Ao A Xu Zhihan Z Wang Tao T Wu Rui R Yang Weiping W

Brain and behavior 20200718 9

<h4>Introduction</h4>Previous studies have confirmed increased functional connectivity in elderly adults during processing of simple audio-visual stimuli; however, it is unclear whether elderly adults maximize their performance by strengthening their functional brain connectivity when processing dynamic audio-visual hand-held tool stimuli. The present study aimed to explore this question using global functional connectivity.<h4>Methods</h4>Twenty-one healthy elderly adults and 21 healthy younger ...[more]

PMID: 32683799

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Project description:The human brain consists of anatomically distant neuronal assemblies that are interconnected via a myriad of synapses. This anatomical network provides the neurophysiological wiring framework for functional connectivity (FC), which is essential for higher-order brain functions. While several studies have explored the scale-specific FC, the scale-free (i.e., multifractal) aspect of brain connectivity remains largely neglected. Here we examined the brain reorganization during a visual pattern recognition paradigm, using bivariate focus-based multifractal (BFMF) analysis. For this study, 58 young, healthy volunteers were recruited. Before the task, 3-3 min of resting EEG was recorded in eyes-closed (EC) and eyes-open (EO) states, respectively. The subsequent part of the measurement protocol consisted of 30 visual pattern recognition trials of 3 difficulty levels graded as Easy, Medium, and Hard. Multifractal FC was estimated with BFMF analysis of preprocessed EEG signals yielding two generalized Hurst exponent-based multifractal connectivity endpoint parameters, H(2) and ΔH 15; with the former indicating the long-term cross-correlation between two brain regions, while the latter captures the degree of multifractality of their functional coupling. Accordingly, H(2) and ΔH 15 networks were constructed for every participant and state, and they were characterized by their weighted local and global node degrees. Then, we investigated the between- and within-state variability of multifractal FC, as well as the relationship between global node degree and task performance captured in average success rate and reaction time. Multifractal FC increased when visual pattern recognition was administered with no differences regarding difficulty level. The observed regional heterogeneity was greater for ΔH 15 networks compared to H(2) networks. These results show that reorganization of scale-free coupled dynamics takes place during visual pattern recognition independent of difficulty level. Additionally, the observed regional variability illustrates that multifractal FC is region-specific both during rest and task. Our findings indicate that investigating multifractal FC under various conditions - such as mental workload in healthy and potentially in diseased populations - is a promising direction for future research.

Dataset Information

Age-related functional brain connectivity during audio-visual hand-held tool recognition.

Publications

Age-related functional brain connectivity during audio-visual hand-held tool recognition.

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