Dataset Information

Autonomic modulation before and after paroxysmal atrial fibrillation events in patients with ischemic heart disease.

ABSTRACT:

Background

The autonomic activity plays a critical role in generating paroxysmal atrial fibrillation (PAF). This study aimed to evaluate the changes in the autonomic nerve activity before and after PAF events in patients with and without ischemic heart disease (IHD).

Methods

The study included 49 patients (71.43 ± 12.24 years old, 26 males) with PAF events lasting more than 30 s during 24-hr ambulatory Holter monitoring. The 20-min intervals before and after PAF events were divided into eight segments of 5 min each. Heart rate variability (HRV) analyses of the time and frequency domains were applied to each time segment.

Results

Patients with IHD had significant increases in the root mean square successive differences (r-MSSD, p = .008) and HF component (p = .04), followed by a significant increase in the LF/HF ratio (p = .02) preceding the onset of PAF. Patients without IHD had only a significant increase in the r-MSSD (p = .045) preceding the onset of PAF. During the termination of PAF events, patients in both the IHD and control groups had a significantly decreased r-MSSD and HF, respectively.

Conclusion

Ischemic heart disease causes a sympathovagal imbalance in the initiation of PAF. Decreased parasympathetic activity regulated the termination of PAF in both the IHD and control groups. The modification of the autonomic nervous system (ANS) activity should be individualized due to the autonomic complexity in AF arrhythmogenesis and termination.

SUBMITTER: Ernie Liao TW

PROVIDER: S-EPMC7507060 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Publications

Autonomic modulation before and after paroxysmal atrial fibrillation events in patients with ischemic heart disease.

Ernie Liao Ting-Wei TW Lo Li-Wei LW Lin Yenn-Jiang YJ Chang Shih-Lin SL Hu Yu-Feng YF Wu Cheng-I CI Chung Fa-Po FP Chao Tze-Fan TF Liao Jo-Nan JN Chen Shih-Ann SA

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20200526 5

<h4>Background</h4>The autonomic activity plays a critical role in generating paroxysmal atrial fibrillation (PAF). This study aimed to evaluate the changes in the autonomic nerve activity before and after PAF events in patients with and without ischemic heart disease (IHD).<h4>Methods</h4>The study included 49 patients (71.43 ± 12.24 years old, 26 males) with PAF events lasting more than 30 s during 24-hr ambulatory Holter monitoring. The 20-min intervals before and after PAF events were divide ...[more]

PMID: 32452603

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Dataset Information

Autonomic modulation before and after paroxysmal atrial fibrillation events in patients with ischemic heart disease.

Background

Methods

Results

Conclusion

Publications

Autonomic modulation before and after paroxysmal atrial fibrillation events in patients with ischemic heart disease.

Similar Datasets

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