Ontology highlight
ABSTRACT:
SUBMITTER: Griffiths DR
PROVIDER: S-EPMC7507085 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Griffiths Daniel R DR Jenkins Taylor M TM Addington Caroline P CP Stabenfeldt Sarah E SE Lifshitz Jonathan J
Brain and behavior 20200723 9
<h4>Introduction</h4>The extracellular matrix (ECM) provides structural support for neuronal, glial, and vascular components of the brain, and regulates intercellular signaling required for cellular morphogenesis, differentiation and homeostasis. We hypothesize that the pathophysiology of diffuse brain injury impacts the ECM in a multi-dimensional way across brain regions and over time, which could facilitate damage and repair processes.<h4>Methods</h4>Experimental diffuse TBI was induced in mal ...[more]