Anthocyanins increase serum adiponectin in newly diagnosed diabetes but not in prediabetes: a randomized controlled trial.

ABSTRACT: Background:Epidemiological studies have suggested that adiponectin is associated with the development of insulin resistance and type 2 diabetes. This study first examined the effect of purified anthocyanins, a group of dietary flavonoids, on serum adiponectin in patients with prediabetes and newly diagnosed diabetes. Methods:A total of 160 patients with prediabetes (n?=?90) or newly diagnosed diabetes (n?=?70) were randomly assigned to either the anthocyanins group or the placebo group for 12 weeks of intervention. Serum adiponectin, a set of biomarkers related to glucolipid metabolism, anthropometric parameters, dietary intake and physical activity were measured before and after intervention. Results:Anthocyanins increased serum adiponectin compared with placebo (net change 0.46 µg/mL, 95% CI [0.03, 0.90], p?=?0.038) in the subjects with newly diagnosed diabetes. No significant difference in the change in adiponectin was observed between the two groups either in the overall subjects (0.02 µg/mL [-?0.32, 0.36], p?=?0.906) or in prediabetes (-?0.35 µg/mL [-?0.85, 0.16], p?=?0.174). Anthocyanins also decreased fasting glucose (-?0.5 mmol/L [-?1, -?0.04], p?=?0.035) in the subjects with newly diagnosed diabetes, but no such change was observed in those with prediabetes. Conclusions:Anthocyanins supplementation for 12 weeks improved serum adiponectin and fasting glucose in patients with newly diagnosed diabetes, but not in patients with prediabetes. Trial registration:ClinicalTrials.gov, NCT02689765. Registered on 6 February 2016, https://clinicaltrials.gov/ct2/show/NCT02689765.

SUBMITTER: Yang L 

PROVIDER: S-EPMC7507266 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature