Ontology highlight
ABSTRACT:
SUBMITTER: Baidya M
PROVIDER: S-EPMC7507470 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Baidya Mithu M Kumari Punita P Dwivedi-Agnihotri Hemlata H Pandey Shubhi S Pandey Shubhi S Chaturvedi Madhu M Stepniewski Tomasz Maciej TM Kawakami Kouki K Cao Yubo Y Laporte Stéphane A SA Selent Jana J Inoue Asuka A Shukla Arun K AK
EMBO reports 20200726 9
β-arrestins (βarrs) are key regulators of G protein-coupled receptor (GPCR) signaling and trafficking, and their knockdown typically leads to a decrease in agonist-induced ERK1/2 MAP kinase activation. Interestingly, for some GPCRs, knockdown of βarr1 augments agonist-induced ERK1/2 phosphorylation although a mechanistic basis for this intriguing phenomenon is unclear. Here, we use selected GPCRs to explore a possible correlation between the spatial positioning of receptor phosphorylation sites ...[more]